I have a larger ornamental pear tree that has lost leaves at the end of branches. This is present over the entire tree. Is there any thing I can do? Should we prune the "dead" ends of branches, etc.?
Most likely, the pear is a deciduous tree that will lose its leaves each winter. If the tips of the branches exhibited browning/defoliation during the growth season, it would be of more concern for a potential pathogen.
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